Protein Details: Potassium voltage-gated channel subfamily C member 1

Protein ID

ICDB_Pro_0354

Protein Name

Potassium voltage-gated channel subfamily C member 1

Gene Name

Kcnc1

Organism

Mus musculus (Mouse)

Length

511 amino acids

AlphaFoldDB

AF-P15388-F1-model_v4.pdb

Function

Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane; forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient . Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNC2; and possibly other family members as well. Contributes to fire sustained trains of very brief action potentials at high frequency in pallidal neurons

Sequence

MGQGDESERIVINVGGTRHQTYRSTLRTLPGTRLAWLAEPDAHSHFDYDPRADEFFFDRHPGVFAHILNYYRTGKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFGGAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDPYSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEAFLTYIEGVCVVWFTFEFLMRVVFCPNKVEFIKNSLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKKKHIPRPPQLGSPNYCKSVVNSPHHSTQSDTCPLAQEEILEINRAGRKPLRGMSI

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Detected in cerebellum (PubMed:11517255; PubMed:15217387). Detected in brain (at protein level) (PubMed:9037088). Detected in brain (PubMed:9037088).

DOI ID

10.1016/0014-5793(89)81488-7; 10.1371/journal.pbio.1000112; 10.1016/s0021-9258(19)36784-5; 10.1073/pnas.94.4.1533; 10.1523/jneurosci.21-17-06657.2001; 10.1111/j.0953-816x.2004.03385.x; 10.1111/j.1601-183x.2005.00184.x; 10.1016/j.cell.2010.12.001

RefSeq

NP_032447.1 [P15388-1]